Question: Does Serum Sickness Get Worse?

Can serum sickness last for months?

Treatment of serum sickness-like reaction Affected children usually recover within a few days of ceasing the offending medication, without any consequences.

There have been reports of prolonged rash and/or joint symptoms lasting for several months but these have eventually resolved completely..

What is serum sickness syndrome?

Serum sickness is an immune-complex-mediated hypersensitivity reaction that classically presents with fever, rash, polyarthritis or polyarthralgias. It was first recognized as an entity in the early 1900s in patients who had received heterologous antisera, which was historically used to treat infectious diseases.

What does serum sickness look like?

Key Points. The key features of serum sickness and serum sickness-like reactions (SSLRs) are rash, fever and polyarthritis. Signs and symptoms of true serum sickness occur one to two weeks after first exposure, while SSLRs usually develop after 5 to 10 days.

Can you get serum sickness from a bee sting?

Reactions occurring more than four hours after a bee or other insect sting are classified as delayed reactions. There have been isolated reports of serum sickness-like syndromes occurring about a week after a sting.

Is serum sickness an autoimmune disease?

Serum sickness is an immune complex–mediated hypersensitivity reaction characterized by fever, rash, arthritis, arthralgia, and other systemic symptoms. … With regard to patient education on serum sickness, the patient and his or her family should be advised of the nature of the offending agent.

How do you prevent serum sickness?

Prevention. Avoidance of antitoxins that may cause serum sickness is the best way to prevent serum sickness. Although, sometimes, the benefits outweigh the risks in the case of a life-threatening bite or sting. Prophylactic antihistamines or corticosteroids may be used concomitant with the antitoxin.

Why does serum sickness occur?

During serum sickness, the immune system falsely identifies a protein in antiserum as a harmful substance (antigen). The result is an immune system response that attacks the antiserum. Immune system elements and the antiserum combine to form immune complexes, which cause the symptoms of serum sickness.

How do you get serum sickness?

Serum sickness is an immune response that’s similar to an allergic reaction. It happens when antigens (substances that trigger an immune response) in certain medications and antiserums cause your immune system to react. The antigens involved in serum sickness are proteins from nonhuman sources — usually animals.

Can a bee sting cause serum sickness?

Serum sickness is a type of delayed reaction that occurs a week to 10 days after a sting and may cause itching, rash, fever, joint pain, fatigue, and swollen lymph nodes.